La subunidad RPB1 de la ARN polimerasa II (POLR2A) es una enzima codificada en humanos por el gen polr2A. Esta proteína se corresponde con la subunidad de mayor tamaño de la ARN polimerasa II, la polimerasa responsable de sintetizar el ARNm en eucariotas. POLR2A contiene un dominio en el extremo C-terminal compuesto de repeticiones de un heptapéptido que es esencial en la actividad de la polimerasa.
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