El factor de transcripción II B (TFIIB o GTF2B) es uno de los diversos factores de transcripción generales que conforma el complejo de pre-iniciación de la ARN polimerasa II. Es codificado en humanos por el gen HUGO TFIIB . El factor de transcripción IIB se localiza en el núcleo celular, donde forma un complejo (el complejo DAB) con los factores de transcripción IID y IIA.
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