El inhibidor 2A de quinasa dependiente de ciclina, también denominado CDKN2A o p16 es una proteína supresora de tumores codificada en humanos por el gen CDKN2A. p16 tiene un papel importante en la regulación del ciclo celular. Las mutaciones en p16 aumentan el riesgo de desarrollar diversos cánceres, especialmente melanomas.
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