El factor intrínseco gástrico o factor intrínseco de Castle (llamado así en honor a William Bosworth Castle 21 de octubre de 1897 9 de agosto de 1990 en reconocimienmto a sus contribuciones) es una glucoproteína producida por las células parietales de la mucosa gástrica, la cual es necesaria para la absorción intestinal de la cianocobalamina o vitamina B12.
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