Apaf-1
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La proteína Apaf-1 (Apoptosis protease-activating factor-1) es un regulador clave de la vía apoptótica mitocondrial, siendo el elemento central del complejo multimérico denominado apoptosoma, formado también por la procaspasa-9 y el citocromo c. Las actividades Apaf se describieron por primera vez en experimentos in vitro para recuperar la actividad caspasa a partir de fracciones citosólicas de células HeLa. Apaf-1 resultó ser una molécula adaptadora con homología con la proteína CED-4 de C.
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